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Which phase involves testing a drug on a large number of patients to evaluate its effectiveness and monitor for adverse effects compared to existing treatments?

  1. Clinical Phase 1

  2. Clinical Phase 2

  3. Clinical Phase 3

  4. Preclinical Investigation

The correct answer is: Clinical Phase 1

Clinical Phase 1 typically involves testing a drug for the first time in a small group of healthy volunteers to evaluate safety, dosage range, absorption, metabolism, and excretion. Clinical Phase 2 is when the drug is tested on a larger group of patients to evaluate its efficacy and side effects. Clinical Phase 3, the correct answer, involves testing the drug on a large number of patients to further evaluate effectiveness, monitor side effects, compare it to existing treatments, and collect information that will allow it to be used safely. Preclinical investigation occurs before any human testing and involves laboratory and animal studies to gather information on the drug's safety profile and potential effectiveness.